Nationwide Researcher of the 12 months 2022 Decodes Drug Resistance in Animals – A Step in the direction of Sustainable Options

Home science Genetics Nationwide Researcher of the 12 months 2022 Decodes Drug Resistance in Animals – A Step in the direction of Sustainable Options
Nationwide Researcher of the 12 months 2022 Decodes Drug Resistance in Animals – A Step in the direction of Sustainable Options
Nationwide Researcher of the 12 months 2022 Decodes Drug Resistance in Animals – A Step in the direction of Sustainable Options

Newswise – Chula Veterinary Lecturer and “National Outstanding Researcher 2022” has revealed the genetic code that causes drug resistance in animals that impacts human and animal well being and the atmosphere, and proposes complete options below the “One Health” idea.

drug resistance It’s a silent menace that the World Well being Group (WHO) says kills 700,000 individuals yearly. If not addressed, drug resistance deaths are anticipated to succeed in a million individuals yearly worldwide within the subsequent 30 years or roughly 2050. For Thailand, preliminary research have discovered that deaths from drug resistance have reached a file degree of about 30,000 individuals per 12 months! So urgently discovering a mitigating technique to take care of the issue is important to stopping a public well being disaster sooner or later.

“Drug resistance is one health problem that links people’s health with the health of animals and the environment. If we don’t try to find a solution to drug resistance right now, we may not have antibiotics to treat infectious diseases either in humans or animals in the future,” a. Dr.. Rungtip Chuanchuen, Chair, Division of Veterinary Public Well being, School of Veterinary Sciences, Chulalongkorn College.

Along with her experience in drug-resistant pathogens in animals, together with a wealth of analysis that has been remodeled into nationwide and worldwide motion plans, Prof. Rongthep has held a number of key positions, together with director of the Meals Antimicrobial Resistance Surveillance Heart. Pathogens (in collaboration with WHO), Director of the FAO Antimicrobial Resistance Reference Heart, Director of the World Community on Foodborne Infections: Southeast Asia and Western Pacific Area, WHO, and so forth. Just lately, it has been named “2022 National Outstanding Researcher in Agriculture and Biology” by the Nationwide Analysis Council of Thailand (NRCT) together with her analysis on molecular biology decoding sustainable options to drug resistance.

Animal drug resistance issues in Thailand

Prof. Dr. Rongthep defined that using antibiotics in farmed animals, whether or not livestock or aquatic animals, is primarily geared toward treating and stopping an infection and accelerating the expansion of animals, however the issue of antibiotic resistance arises from using antibiotics with out correct motive.

“Every time antibiotics are used they provide an opportunity to develop resistance and spread resistance genes. In livestock farms, antibiotics are also used. Farmers and consumers may also be exposed to drug-resistant pathogens through the food chain from consuming contaminated meat or from direct contact that harms their health “.

Furthermore, pets and wildlife, as well as the natural environment, such as soil and water, may also be contaminated with drug-resistant pathogens. These pathogens can have their effects either in humans, animals or the environment.

Molecular biology and solving the problem of drug-resistant pathogens

Solving the problem of drug resistance in farm animals is not easy. As the livestock industry still needs to use antibiotics, the challenge is up to the researchers. Prof. Dr. Rongthep conducted research to find solutions to drug resistance with knowledge in genetics combined with microbiological techniques to answer the question why some drug-resistant pathogens are prevalent in Thailand, and how factors other than antibiotics can cause drug resistance.

“We have studied drug resistance at the genome level and have used genetic engineering to study the genetic characteristics of drug resistance and drug resistance mechanisms to better understand the origin of drug resistance, genetic relationships and heredity, which can be used to develop new molecules or antibiotics, including alternatives to antibiotics.”

Prof. Dr. Rongthep recounted findings from genetic analysis of resistant organisms collected from humans, livestock and animal foods in Thailand and the ASEAN region using nano-hole sequencing techniques: “The genomic characteristics of resistant organisms in Thailand and other ASEAN countries are diverse, with some similar genetic elements representing gene circulation. resistance in the region.

Professor Rongthep explained that not only antibiotics but other factors can cause pathogens to develop drug resistance, transfer genes or drug resistance determinants, leading to the spread of drug resistance, especially in disinfectants used in farms and hospitals, as well as heavy metals found in animal feed.

“Based on preliminary data, we have detected the presence of antibiotic resistance genes in dust collected from livestock farms, as well as dust from air conditioners in research laboratories. We are now expanding our research to clinics and hospitals. Antibiotic-resistant pathogens are not only found in animals. and animal foods, so banning the use of antibiotics in livestock alone may not be the answer to all antibiotic resistance problems.”

To the national strategic plan to combat drug resistance

Professor Dr. Rongthep’s research has been used to support Thailand’s strategic plan to mitigate antibiotic resistance and tackle antibiotic resistance in Asia and other developing countries in the region, in collaboration with FAO and other international agencies. The plan consists of the evaluation of national antibiotic resistance surveillance and antibiotic resistance laboratory systems, the development of measures to control the use of antibiotics in animals, an action plan for the surveillance of antibiotic resistance under the One Health concept, etc.

In addition, research findings were also published to advance knowledge and understanding of drug resistance and the proper use of antibiotics for young people, the general public, pet owners, and public and private sector workers.

“Effective treatment of drug resistance in livestock requires many factors, and cooperation from many sectors, including monitoring and control of drug resistance, reasonable use of antibiotics, enhancing farm biosecurity, reducing infection and enhancing immunity in animals, use of alternatives to antibiotics, etc. .”

“Drug resistance is a well being drawback for people, animals and the atmosphere. Prof. Rongthep concluded: “Options have to be built-in throughout the framework of the ‘One Health Concept’, which should concurrently deal with drug resistance in people, animals and the atmosphere.”

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